Molecular and Cellular Gynecological

Endocrinology Laboratory

 

Publications

 

Original papers

  1. P.Mannella A.M. Sanchez, M.S. Giretti, A.R. Genazzani, T.Simoncini. Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons depending on prior hormonal exposure via the induction of neural nitric oxide synthase Steroids 2009

  2. Kublickiene K, Fu XD, Svedas E, Landgren BM, Genazzani AR, T. Simoncini. Effects in postmenopausal women of estradiol and medroxyprogesterone alone and combined on resistance artery function and endothelial morphology and movement. J Clin Endocrinol Metab. 2008, 93(5):1874-83  

  3. M.I. Flamini, X-D. Fu, A.M. Sanchez, M.S. Giretti, L. Goglia, S. Pisaneschi, V. Tosi, A.R. Genazzani, T.Simoncini. Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton. J Cell Mol Med. 2008, Sep 15

  4.  X-D. Fu, M.S. Giretti, C. Baldacci, S. Garibaldi, M. Flamini, A.M. Sanchez, A. Gadducci, A.R. Genazzani, T. Simoncini. Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton. PLoS ONE. 2008 Jul 30;3(7):e2790.

  5.  X-D. Fu, M.S. Giretti, L. Goglia, M.I. Flamini, A.M. Sanchez, C. Baldacci, S. Garibaldi, R. Sitruk-Ware, A.R. Genazzani, T. Simoncini. Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion. BMC Cancer. 2008, 9;8(1):166

  6. M.S. Giretti, X-D. Fu, G. De Rosa, I. Sarotto, C. Baldacci, S. Garibaldi, P.Mannella, N. Biglia, P. Sismondi, A.R. Genazzani, T. Simoncini. Extra-nuclear signaling of estrogen receptor to breast cancer cytoskeletal remodeling, migration and invasion. PLoS ONE. 2008, 21(3):e2238      

  7. T. Simoncini, S. Garibaldi, X-D. Fu, S. Pisaneschi, S. Begliuomini, C. Baldacci, E. Lenzi, L. Goglia, M.S. Giretti, A.R. Genazzani. Effects of phytoestrogens derived from red clover on atherogenic adhesion molecules in human endothelial cells. Menopause. 2008, 15(3):542-50

  8. Fu XD, Flamini M, Sanchez AM, Goglia L, Giretti MS, Genazzani AR, T. Simoncini. Progestogens Regulate Endothelial Actin Cytoskeleton and Cell Movement via the Actin-Binding Protein Moesin. Mol Hum reprod. 2008, 14(4):225-34

  9.   T. Simoncini, X.-D. Fu, A. Caruso, S. Garibaldi, C. Baldacci, M.S. Giretti, P. Mannella, M.I. Flamini, A.M. Sanchez, A.R. Genazzani. Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Human Reproduction.  2007, 22(8):2325-34      

  10.  Y. Hiroi, H.-H. Kim, H. Ying, F. Furuya, Z. Huang, T. Simoncini, K. Noma, K. Ueki, N.-H. Nguyen, T. Scanlan, M. Moskowitz, S.-Y. Cheng, J.K. Liao. Rapid Nongenomic Actions of Thyroid Hormone. Proceedings of the National Academy of Sciences USA.  2006 103(38):14104-9

  11.  T. Simoncini, A. Caruso, S. Garibaldi, X.D. Fu, M.S. Giretti, C. Baldacci, C. Scorticati, L. Fornari, P. Mannella,  A.R. Genazzani. Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate. Obstetrics & Gynecology. 2006 108(4):969-78.

  12. T. Simoncini, A. Caruso, M.S. Giretti, C. Scorticati, X.D. Fu, S. Garibaldi, C. Baldacci, P. Mannella, L. Fornari, A.R. Genazzani. Comparative effects of dydrogesterone and of its stable metabolite, 20α-dihydro-dydrogesterone vs. progesterone and medroxyprogesterone acetate on nitric oxide synthesis in human endothelial cells. Fertility & Sterility. 2006. 86, 4: 1235-1242

  13. T. Simoncini, C. Scorticati, P. Mannella, A. Fadiel, M.S. Giretti, X.D. Fu, C. Baldacci, S. Garibaldi, A. Caruso, L. Fornari, F. Naftolin, A.R. Genazzani. Estrogen Receptor Alpha Interacts with Gα13 to Drive Actin Remodeling and Endothelial Cell Migration via the RhoA/Rho Kinase/Moesin Pathway. Molecular Endocrinology. 2006 20, 8:1756-1771 

  14. M. Michelini, A. Rosellini, V. Mandys, T. Simoncini, R.P. Revoltella. Cytoarchitecture modifications of the human uterine endocervical mucosa in long-term three-dimensional organotypic culture. Pathology Research and Practice. 2005 201:679-689.

  15. T. Simoncini, L. Fornari, P. Mannella, G. Varone, A. Caruso, S. Garibaldi, A.R. Genazzani. Differential estrogen signaling in endothelial cells upon pulsed or continuous administration. Maturitas. 2005 50:247-258.

  16. T. Simoncini, L. Fornari, P. Mannella, A. Caruso, S. Garibaldi, C. Baldacci, A.R. Genazzani. Activation of nitric oxide synthesis in human endothelial cells by red clover extracts. Menopause. 2005 12:69-77. 

  17. T. Simoncini, P. Mannella, L. Fornari, A. Caruso, M.Y. Willis, S. Garibaldi, C. Baldacci, A.R. Genazzani. Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004 145:5745-56.

  18. T. Simoncini, P. Mannella, L. Fornari, A. Caruso, G. Varone, S. Garibaldi, A.R. Genazzani. Tibolone activates nitric oxide synthesis in human endothelial cells. J Clin Endocrinol Metab. 2004 89: 4594-4600.

  19. M. Michelini, A. Rosellini, T. Simoncini, S. Papini, R.P. Revoltella. A three-dimensional organ culture system of the human uterine exocervix for studying mucosal epithelial differentiation and migrating leukocytes. Differentiation. 2004 72:138-49.

  20. T. Simoncini, P. Mannella, L. Fornari, G. Varone, A. Caruso, A.R. Genazzani. Dehydroepiandrosterone (DHEA) modulates endothelial nitric oxide synthesis via direct genomic and non-genomic mechanisms. Endocrinology. 2003 144:3449-3455.

  21.  T. Simoncini, E. Rabkin, JK Liao. Molecular Basis of Cell Membrane Estrogen Receptor Interaction with Phosphatidylinositol 3-Kinase in Endothelial Cells, Arterioscler, Thromb Vasc Biol, 2003 198-203

  22. F.P. Limbourg, Z. Huang, J.C. Plumier, T. Simoncini, M. Fujioka, J. Tuckermann, G. Shutz, M.A. Moskowitz, J.K Liao. Rapid non-transcriptional activation of endothelial nitric oxide synthase mediates increased in cerebral blood flow and stroke protection by corticosteroids, J Clin Invest 2002 Dec;110(11):1729-38.

  23. T. Simoncini, G. Varone, L. Fornari, P. Mannella, M. Luisi, F. Labrie, A.R. Genazzani. Genomic and non-genomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth generation selective estrogen receptor modulator. Endocrinology. 2002 143:2052-2061.

  24. A. Hafezi-Moghadam, T. Simoncini, Z. Yang, F.P. Limbourg, J.-C. Plumier, M.C. Rebsamen, C.-M. Hsieh, D.-S. Chui, K.L. Thomas, A.J. Prorock, V.E. Laubach, M.A. Moskowitz, B.A. French, K. Ley, J.K. Liao. Cardiovascular protective effects of corticosteroids mediated by nontranscriptional activation of endothelial nitric oxide synthase. Nature Medicine. 2002 8:473-1479.

  25. T. Simoncini, A.R. Genazzani, J.K. Liao. Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene. Circulation. 2002 105:1368-1373.

  26.  G. Basta, G. Lazzerini, M. Massaro, T. Simoncini, P. Tanganelli, C. Fu, T. Kislinger, D.M. Stern, A.M. Schmidt, R. De Caterina. Advanced glycation end products activate endothelium through signal-transduction receptor. A mechanism for amplification of inflammatory responses. Circulation. 2002 105:816-822.

  27. T. Simoncini, A. Hafezi-Moghadam, D. Brazil, K. Ley, W.W. Chin, J.K. Liao. Interaction of Estrogen Receptor with the Regulatory Subunit of Phosphatidylinositol 3-Kinase. Nature. 2000 407:538-541.

  28. D.E. Marra, T. Simoncini, J.K. Liao. Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21Waf1 and p27Kip1. Circulation, 2000 102:2124-2130.

  29. T. Simoncini, A.R. Genazzani. Raloxifene Acutely Stimulates Nitric Oxide Release from Human Endothelial Cells Via an Activation of Endothelial Nitric Oxide Synthase. J Clin Endocrinol Metab, 2000 85(8):2966-2969.

  30. T. Simoncini, S. Maffei, G. Basta, G. Barsacchi, A.R. Genazzani, J.K. Liao, R. De Caterina. Estrogens and Glucocorticoids Inhibit Endothelial Vascular Cell Adhesion Molecule-1 Expression by Different Transcriptional Mechanisms. Circ Research, 2000 87(1):19-25.

  31. T. Simoncini, A.R. Genazzani. Tibolone Inhibits Leukocyte Adhesion Molecule Expression in Human Endothelial Cells. Mol Cell Endocrinol, 2000 162:87–94.

  32. U. Laufs, M. Endres, N. Stagliano, S. Amin-Hanjan, D.S. Chui, S.X. Yang, T. Simoncini, M. Yamada, E. Rabkin, P.G. Allen, P.L. Huang, M. Böhm, F.J. Schoen, M.A. Moskowitz, J.K. Liao. Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J. Clin. Invest. 2000 106:15–24.

  33. P. Florio, S. Rivest, F.M. Reis, T. Simoncini, P. Martinelli, A.R Genazzani, F. Petraglia. Lack of gestation-related changes of urocortin gene expression in human placenta. Prenat Neonat Med, 1999 4:296-300.

  34. T. Simoncini, R. Apa, F. Reis, F. Miceli, M. Stomati, L. Driul, A. Lanzone, A.R Genazzani, F. Petraglia. Human umbilical vein endothelial cells: a new source and potential target for corticotropin-releasing factor. J Clin Endocrinol Metab, 1999 84(8):2802-6.

  35. T. Simoncini, R. De Caterina, A.R. Genazzani. Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. J Clin Endocrinol Metab, 1999; 84(2):815-8. 

  36. F. Petraglia, P. Florio, T. Simoncini, R.J. Woods, A. Giuntini, R. Gremigni, G.B. Serra, A.R. Genazzani, P.J. Lowry. Cord plasma corticotropin-releasing factor-binding protein (CRF-BP) in term and preterm labor. Placenta, 1997;18:115-119.

  37. F. Petraglia, P. Florio, R. Gallo, T. Simoncini, M. Saviozzi, A.M. Di Blasio, J. Vaughan, W. Vale. Human placenta and fetal membranes express human urocortin mRNA and peptide. J Clin Endocrinol Metab, 1996; 10:3807-3810.

 

Reviews

 

  1. M. L’Hermite, T. Simoncini, S. Fuller, A.R. Genazzani. Could transdermal estradiol + progesterone be a safer postmenopausal HRT? A review. Maturitas, 2008, Sep 4  

  2. X-D- Fu, T. Simoncini. Extranuclear signaling of sex steroids, IUBMB Life, 2008, 60(8):502-10. 

  3. M.S. Giretti, T. Simoncini. Rapid regulatory actions of sex steroids on cell movement through the actin cytoskeleton, Steroids, 2008, 73(9-10):895-900. 

  4. M.S. Giretti, A.R. Genazzani, T. Simoncini. Impatto delle terapie ormonali sulla patologia benigna della mammella Il Ginecologo 2007; 2 (2):96-104. 

  5. T. Simoncini, P.Mannella, N. Pluchino, AR. Genazzani. Comparative effects of dydrogesterone and medroxyprogesterone acetate in critical areas: The brain and the vessels. Gynecological Endocrinology 2007; 23 Suppl 1:9-16.

  6.   AR. Genazzani, P.Mannella, T. Simoncini. Drospirenone and its antialdosterone properties. Climacteric 2007; 10 Suppl 1:11-8.

  7.  X. Fu, T. Simoncini. Non-genomic sex steroid actions in the vascular system. Sem Reprod Med. 2007; 25:178-186.

  8. Gambacciani M, Mannella P. Homocysteine, menopause and cardiovascular disease. Menopause Int. 2007 Mar;13(1):23-6

  9. T. Simoncini, P. Mannella, A.R. Genazzani. Terapia ormonale sostitutiva: le proposte del ginecologo e le aspettative della paziente Aggiornamento Medico 2006; 30 (8):286-295.

  10. T. Simoncini, P. Mannella, A.R. Genazzani. Terapia ormonale sostitutiva in menopausa, attualità. La Medicina Estetica, 2006, 3:397-402. 

  11. T. Simoncini, P. Mannella, A.R. Genazzani. Terapia ormonale sostitutiva: le proposte del ginecologo e le aspettative della paziente Il Ginecologo 2006; 1 (2):95-102.

  12. T. Simoncini, A.R. Genazzani. Menopausa, terapia ormonale sostitutiva e rischio cardiovascolare. Basi biologiche ed evidenze cliniche, Giornale

  13. T. Simoncini, P. Mannella, L. Fornari, A. Caruso, G. Varone, A.R. Genazzani. Genomic and nongenomic effects of estrogens on endothelial cells, Steroids, 2004, 69: 537-542

  14. T. Simoncini, P. Mannella, L. Fornari, A. Caruso, G. Varone, A.R. Genazzani. In vitro effects of progesterone and progestins on vascular cells, Steroids, 2003, 68:831-836.

  15. T. Simoncini, A.R. Genazzani. Nongenomic actions of sex steroid hormones, Eur J Endocrinol, 2003, 148:281-292.

  16. T. Simoncini, L. Fornari, P. Mannella, G. Varone, A. Caruso, J.K. Liao, A.R. Genazzani Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system: Interaction of estrogen receptor with phosphatidylinositol 3-OH kinase, Steroids, 2002, 67;935-939.

  17. T. Simoncini, A.R. Genazzani. Direct Vascular Effects of Estrogens and SERMs. Curr Opin Obstet Gynecol, 2000;12:181-187.

  18. T. Simoncini, A.R. Genazzani, R. De Caterina. Towards a Molecular Understanding of the Atheroprotective Effects of Estrogens: a Review of Estrogen Effects on Endothelial Activation. Ital Heart J. 2000;1(2):104-107

  19. Petraglia, M. Santuz, P. Florio, T. Simoncini, S. Luisi, L. Plaino, A.R. Genazzani, A.D. Genazzani, A. Volpe. Paracrine regulation of human placenta: control of hormonogenesis. J Reprod Immunol, 1998;39(1-2):221-33.

  20. Petraglia, T. Simoncini, P. Florio, A. Gallinelli, A. Giuntini, R. Gremigni, A. Volpe, A.R. Genazzani. Placental stress factors and human parturition. Ann N Y Acad Sci. 1997; 26;828:230-7.

  

OTHER INTERNATIONAL PUBLICATIONS

 

1.      T. Simoncini, C. Baldacci, A.R. Genazzani. Safety and security of menopausal therapies. European Endocrine Disease 2007, Touch Briefings  2007; 1: 83-86.

 

2.      T. Simoncini, P. Mannella, A.R. Genazzani. Current issues and new developments in the endocrine care of climacteric women. European Endocrine Disease 2006, Touch Briefings  2006; 1: 74-76.

 

3.      T. Simoncini, A.R. Genazzani. Tibolone inhibits ELAM expression. Menopause Digest 2001; 13, 3: 21-2.