SEALANTS

Last update: 02/21/2009

 

Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. Endoscopy. 2008 Dec;40(S 02):E262. Epub 2008 Dec 17. No abstract available. 

Case report of uncontrollable pelvic bleeding - managed by a previously unreported method (QuikClot(R).

Colorectal Dis. 2008 May 3. [Epub ahead of print] The authors felt that "internal" use of Quikclot in this situation might be life-saving and was applied to the bleeding area, stopping the bleeding immediately.

Hemostats, sealants, and adhesives: components of the surgical toolbox.

Transfusion. 2008 Apr 14; [Epub ahead of print] More operations are being performed through minimally invasive incisions with laparoscopic, endoscopic, and robotic approaches. In this setting, tools that can reduce bleeding by causing blood to clot, sealing vessels, or gluing tissues are gaining an increasing importance. Thus, hemostats, sealants, and adhesives are becoming a more important element of surgical practice. This review is designed to facilitate the reader's basic knowledge of these tools so that informed choices are made for controlling bleeding in specific clinical situations. Such information is useful for all members of the operative team.

QuikClot use in trauma for hemorrhage control: case series of 103 documented uses.

J Trauma. 2008 Apr;64(4):1093-9. Local hemostatics have recently been introduced for field use to control external hemorrhage. The objective of this report is to describe the initial clinical experience with QuikClot, a zeolite that works by absorbing water and concentrating coagulation factors to stop bleeding in a series of patients. QuikClot has been effectively used by a wide range of providers in the field and hospital to control hemorrhage.
Use of a collagen-sealing device in hepatic resection: a comparative analysis to standard resection technique.
HPB (Oxford). 2006;8(3):194-9. Use of a collagen- sealing device has the potential to further reduce blood loss and transfusion requirements without increasing operative time.

Efficacy of a haemostatic matrix for the management of bleeding in patients undergoing liver resection: results from 237 cases.

Curr Med Res Opin. 2008 Feb 19; [Epub ahead of print] In this prospective, uncontrolled study of 237 consecutive patients undergoing major hepatic surgery to remove primary or metastatic tumours, application of a haemostatic matrix (Floseal - Baxter) provided rapid and effective intraoperative control of mild to severe bleeding from the liver edge, even in patients with prolonged bleeding times resulting from cirrhosis.

A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury.

J Trauma. 2008 Jan;64(1):75-80. Fibrin patch with packing effectively controlled coagulopathic bleeding and prevented death in a model of grade V liver injury in which hepatic packing alone (standard of care) was ineffective.

The use of fibrin sealant in burn operations.

Surgery. 2007 Oct;142(4 Suppl):S50-4. Blood loss can be reduced dramatically with the use of topical sealants.

High-Pressure Fibrin Sealant Foam: An Effective Hemostatic Agent for Treating Severe Parenchymal Hemorrhage.
J Surg Res. 2007 Jun 19; [Epub ahead of print]

Fibrin sealant use for minimising peri-operative allogeneic blood transfusion.
Cochrane Database Syst Rev. 2003;(2):CD004171. Review. Overall the results suggest that fibrin sealants are efficacious in reducing both post-operative blood loss and peri-operative exposure to allogeneic RBC transfusion. However, due to the lack of blinding, transfusion practices may have been influenced by knowledge of the patient's treatment status. This raises concerns about the use of blood transfusion practice as an outcome variable in trials of fibrin sealant.